One of the major challenges in neuroscience is to understand the biophysical mechanisms and algorithms underlying neural computation. In my laboratory, we use mathematical models, analysis, and computer simulations to examine the dynamics of neurons and neuronal networks and to understand the mechanisms underlying changes in neuron or network behavior due to trauma, rehabilitation, plasticity or development. Our current research focuses on several related topics including 1) how alterations in dendritic morphology, synapse distributions and membrane properties affect cell dynamics and 2) the roles of synaptic activity, intracellular calcium, and neuromodulators in plasticity and development.

My research group also contributes to an international effort to create standards for describing models in neuroscience. NeuroML, provide a common format for neuroanatomical data, for the biophysical properties of membranes, and for network connectivity. These standards are used by down-stream software applications to aid model exchange and simulator interoperability.